Ulcerative Colitis Flare-Ups: Tips, Treatment, and More

Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD). It causes inflammation and sores called ulcers in your large intestine.

Symptoms of ulcerative colitis typically get worse over time, but they also may disappear for a short or long interval. This period of minimal or no symptoms is called remission.

People with ulcerative colitis often have certain triggers that can cause disease flare-ups. The key to dealing with a flare is knowing what caused it and how to address it.

A UC flare is an acute worsening of the symptoms of bowel inflammation. Flares may occur weeks, months, or even years apart with different levels of severity.

Medication, your lifestyle, eating patterns, and other factors may contribute to flare-ups. In the same way, taking all prescribed medications, eating balanced, nutritious meals, and avoiding known triggers can often help prevent flares.

Ulcerative colitis symptoms change based on the severity of a flare-up and the location of inflammation in the intestine. Symptoms often include:

• bloody diarrhea
• a feeling of needing to pass stools even though your bowels are empty
• needing to pass stools urgently
• abdominal pain or cramps
• tiredness
• fever
• weight loss due to loss of appetite and diarrheal symptoms
• anemia (a lack of red blood cells)

In some cases, you may also experience aching joints, irritated eyes, and mouth ulcers.

Flares occur at different times and may last anywhere from a few days to several months. They can happen anywhere from weeks to years apart, depending on a person’s experience with the condition and the effectiveness of treatment.

Your doctor will work with you to treat your flare and help return your UC to a more manageable state.

If you conceive during a flare-up, you may have more symptoms during pregnancy.

You’re likely to have a healthy pregnancy if you have UC, but you’ll still have a higher chance of complications than someone without the condition. Particularly if your UC is active, you may have a greater risk of:

• miscarriage
• premature birth
• low birth weight for the baby
• complications during labor

In general, UC medications can be taken during pregnancy.

Talk with your doctor about any possible changes to your medications while pregnant.

Ideally, having a conversation with your doctor prior to getting pregnant can allow them to prepare a UC treatment plan in advance that can be revised, if and as needed, during your pregnancy.

It’s important to see your doctor regularly to monitor your UC, even when it’s in remission.

When you first notice a flare, talk with your doctor to determine the cause. They may adjust your medication or suggest other treatment options.

During flare-ups, use wipes rather than toilet paper to reduce irritation. You can also apply a skin protectant at night and take acetaminophen to manage pain. Your doctor can help you determine what measures work well for your specific situation.

It’s also helpful to be aware of things that trigger or worsen your flares so that you can work to avoid them.

Every person with UC has different triggers. Below is a list of some of the most common triggers:

• Medications: Certain medications, like antibiotics, can affect the natural balance of gut flora. Nonsteroidal anti-inflammatory drugs (NSAIDs) and certain other pain relievers are also strongly linked with flares reports the Crohn’s & Colitis Foundation. If certain medications trigger your symptoms, ask your doctor about substitutes.
• Stress: In some people, stress may contribute to flare-ups and increased inflammation.
• Diet: Certain foods may trigger flares or worsen symptoms. Try to identify any foods that affect your UC so you can avoid them.
• Abrupt withdrawal from medications: This can also lead to a flare. It’s especially common when you stop taking steroids or even maintenance therapies.
• Changes in hormone levels during menstruation and pregnancy: This can worsen symptoms or result in a relapse. If you’re thinking about getting pregnant, talk with your doctor first.
• Electrolyte levels: Any condition or infection that alters electrolyte levels in the body can also cause a flare. This includes diarrhea from any infectious or noninfectious cause like traveler’s diarrhea.

Flares may not always be linked to a trigger. Still, being familiar with your triggers may help you reduce and manage flare-ups.

A modified diet may help you manage and reduce your UC symptoms. Depending on your experience with UC, specific foods may trigger flare-ups or worsen symptoms. As a result, it’s important to identify and limit these foods.

Your doctor and a dietitian can work with you to create an eating plan that best manages your symptoms while providing the nutrition you need.

Severe UC flares may keep your body from effectively absorbing enough nutrients. Enteral nutrition, which generally involves a liquid diet given through a tube, can provide needed nutrients while helping your body heal.

Older research suggested that a liquid diet may benefit people with IBD, including severe UC. However, it noted that most studies focus on Crohn’s disease, another type of IBD.

More research is needed for UC.

No specific foods will cure UC or completely stop flares. Still, it’s important to eat a balanced diet both for general health and to help manage your symptoms.

Fruits, vegetables, and whole grains are an important part of a health-promoting diet. However, the high fiber content of raw vegetables may worsen UC flares. Cooking fruits and vegetables can help you keep them in your diet without the impact on your UC.

Make sure you drink enough liquids, especially water. Eating frequent, small meals may also help you feel better.

If UC leads to a nutritional deficiency, your doctor may recommend that you take dietary supplements or vitamins.

Foods that increase UC symptoms may be different for each person. In general, though, it may help to limit or avoid:

• sodas and sugar-sweetened beverages
• dairy
• high fiber foods like raw fruits and vegetables
• spicy food
• fried food
• alcohol, if you consume alcoholic beverages
• caffeine

Keeping a food diary helps you track everything you eat and identify any foods that make your UC worse.

You cannot completely prevent flares without surgery, but you can work toward managing them and reducing symptoms when they occur.

Medications and certain lifestyle changes can help reduce the intensity and frequency of UC flares. Currently, surgery to remove the colon is the only full cure for UC.

There are six main categories of medication used for treatment, some long-term and others short-term. These include:

• Aminosalicylates (5-ASA): There are multiple types of 5-ASA drugs available that get released in different parts of the gastrointestinal tract. They aim to reduce inflammation directly in the colon wall.
• Tofacitinib (Xeljanz): This medication belongs to a class called Janus kinase (JAK) inhibitors. It suppresses specific parts of your immune system to reduce inflammation.
• Corticosteroids: These also help suppress immune system inflammation. They treat active moderate to severe UC, but they can have severe side effects.
• Immunomodulators: These medications modify immune system activity to help reduce its inflammatory response. They’re typically used when other medications have been ineffective.
• Biologics: These drugs modify the immune system response by inhibiting the inflammatory protein TNF-alpha. They can bring about remission quickly, but they may cause a higher risk of infections.
• Antibiotics: These are often used when infections contribute to flares.

You can also use over-the-counter pain relievers like acetaminophen (Tylenol) to help manage pain.

Be sure to tell your doctor about any additional medications you take, including herbs and supplements.

There may be a link between emotional stress and UC flares. Some things you can do to reduce stress include:

According to a 2019 research review, taking probiotics along with aminosalicylates greatly raised UC remission rates. This supports the theory that gut bacteria affect UC. More research is needed on probiotics for UC.

Turmeric may be effective in treating UC, too. A 2020 study found that taking supplements containing curcumin, an active ingredient in turmeric, resulted in improved symptoms and quality of life in people with UC.

You may need surgery if you have colon cancer, serious complications from UC, or severe side effects from medication.

In general, surgery for UC removes your colon and rectum. The procedure is called a proctocolectomy. Because you still need to pass stool, the surgeon will perform either an ileostomy or create an ileoanal reservoir.

In an ileostomy, your surgeon attaches the end of your small intestine, called the ileum, to a hole in your abdomen to make an opening. You’ll need to wear a bag connected to the opening to collect waste.

Alternatively, your surgeon may create an ileoanal reservoir. This pouch, made from your ileum, stores stool inside your body so it can pass through the anus.

Side effects of an ileoanal reservoir may include having bowel movements more often and developing irritation in the pouch.

Below are some commonly asked questions about ulcerative colitis flare-ups.

Ulcerative colitis can cause abdominal pain, tiredness, and fever. During a flare-up, you may experience painful and swollen joints, irritated eyes, and mouth ulcers.

You can manage ulcerative colitis pain with over-the-counter pain relievers like acetaminophen (Tylenol).

Ulcerative colitis can lead to severe and life threatening complications, such as fulminant. This results in more than 10 bloody bowel movements in a day, often with fever, rapid heart rate, and severe anemia, which can lead to hospitalization.

There’s currently no cure for UC, but treatment can often effectively manage symptoms.

Maintaining a health-promoting lifestyle, taking all prescribed medications as directed, and avoiding known triggers can help prevent or reduce flare-ups.

With effective treatment, you could have minimal or no UC symptoms for months or even years at a time.