What to Do If Ulcerative Colitis (UC) Treatment Stopped Working

With ulcerative colitis (UC), you’ll have flare-ups, which are periods when you experience symptoms. Then you’ll have symptom-free periods called remissions.

Nonsurgical treatments do not cure UC, but finding the right medication should help make your flare-ups shorter and less frequent.

Sometimes a treatment you try won’t be the right one for your condition and needs, or the treatment you’re currently using may stop working to treat your condition. If your medication is not helping to manage your flare-ups, here are seven steps you can take to start feeling better again.

UC medications bring down inflammation and allow your colon to heal. Knowing which ones are available and which situations they work best for can help you have a more informed discussion about them with your doctor.

These medications help manage inflammation in people with mild to moderate UC. They may be the first medications you receive.

• by mouth
• as an enema
• as a suppository

• mesalamine (Apriso, Canasa)
• olsalazine (Dipentum)
• balsalazide (Colazal)

These medications help manage more severe symptoms. You should use them for only short periods because they can cause side effects such as weight gain and weakened bones.

Steroid medications are available in a variety of forms, including as a foam, suppository, pill, and syrup. Oral forms are more potent, but they cause more side effects than topical forms.

• budesonide (Uceris)
• prednisone (Prednisone Intensol, Rayos)
• prednisolone (Prelone)
• methylprednisolone (Medrol, Depo-Medrol)

Your doctor may prescribe one of these medications if your UC does not get better with aminosalicylates. They reduce your immune system response to help prevent damage to your colon.

They’re available in oral forms, such as pills and suspensions, and in injectable form.

The Food and Drug Administration (FDA) has not approved immunosuppressants as a UC treatment. However, your doctor may prescribe them anyway if they feel it’s the best option for your care. This is known as off-label drug use.

• methotrexate (Trexall, Otrexup, Rasuvo)
• azathioprine (Azasan, Imuran)
• tacrolimus (Astagraf XL, Envarsus XR, Prograf)

Biologics are used to treat moderate to severe UC when the condition has not improved with other treatments. These medications block an immune system protein that contributes to inflammation.

You can receive biologics as an intravenous infusion or an injection.

Examples of these drugs are:

Tofacitinib belongs to a class of medications known as Janus kinase (JAK) inhibitors. JAK inhibitors work similarly to biologics, blocking an inflammatory protein.

Tofacitinib is available as a tablet or liquid solution under the brand names Xeljanz and Xeljanz XR.

Treating UC is a long-term commitment. Even if you feel well, skipping doses or stopping your medication could cause your symptoms to come back.

When you get a new prescription, make sure you know exactly how and when to take your medication. If you accidentally miss a dose, call your doctor or your pharmacy to find out what to do.

If you develop side effects from the medications, make an appointment with your doctor to discuss switching to another medication. Do not stop taking a medication on your own.

A sudden return of UC symptoms — such as belly pain, diarrhea, and bloody stools — can make it obvious that you’ve entered a flare-up and may need to talk with your doctor about adjusting your treatment. But sometimes the symptoms are more subtle.

Keep track of any changes in the way you feel, no matter how small they are. Let your doctor know if:

• you have more bowel movements than usual
• your bowel movements change in amount or texture
• you notice blood in your stool
• you feel tired or have less energy
• you have less of an appetite or you’ve lost weight
• you have other symptoms, such as joint pain or mouth sores

Writing down your symptoms in a diary can help you explain them to your doctor.

Most people with UC can manage the disease with medication alone. However, surgery may be necessary if other treatments are not working for you or if you experience complications.

The most common type of surgery is the ileal pouch with anal anastomosis, also known as J-pouch surgery. During this procedure, a surgeon removes your colon and rectum and creates an internal pouch to collect your waste and allow for bowel movements. The pouch can take time to get used to.

You may feel hesitant about undergoing surgery. The upside of removing your colon and rectum is that you’ll be “cured” and essentially freed from many symptoms. But since UC affects your immune system, symptoms that extend beyond your digestive system, such as joint pain and skin conditions, may come back after surgery.

If you begin to experience symptoms in your small intestine after surgery, your doctor may update your diagnosis to Crohn’s disease.

Treating UC can take some trial and error. Symptoms come and go, and the disease is more severe in some people than in others.

Schedule regular visits with your doctor to stay on top of your disease. In between visits, keep track of your symptoms and note what seems to trigger them.

The more you know about your disease and the more closely you stick to your treatment, the greater your chances of managing your UC will be.